瑞典专利SE1230030A1 Device for controlling a fluid flow in a space

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专利摘要:
The present invention relates to a device for controlling the flow of a fluid in a compartment (4) with an inlet opening (5) and an outlet opening (6). The device comprises an inlet channel (8) connected to the inlet opening for transportation of fluid to the compartment, an outlet channel (9) connected to the outlet opening for transportation of fluid from the compartment and a pump (17) arranged to pump the fluid. The compartment is provided with a third opening (12). The device comprises a distribution chamber (15) connected to the inlet channel and a third channel (14) connected between the distribution chamber and the third opening for transportation of fluid between the distribution chamber and the compartment. The pump is arranged to vary the fluid flow velocity in the distribution chamber between a lower and a higher flow velocity, and the third channel is arranged so that its transport direction depends upon the flow velocity in the distribution chamber such that the fluid in the third channel is transported in a direction from the distribution chamber to the compartment at said lower flow velocity in the distribution chamber, which leads to a slow flow in the compartment, and in the opposite direction at said higher flow velocity in the distribution chamber due an injector effect, which leads to a substantial increase in the flow velocity in the inlet channel and thus in the compartment.
公开号:SE1230030A1
申请号:SE1230030
申请日:2012-03-22
公开日:2013-03-19
发明作者:Peter Gaardhagen；Eva-Lena Gaardhagen
申请人:Envic Sense Ab；
IPC主号:

专利说明:

The chamber so that the antibodies have time to adhere to the surface of the sensor. Instead, if light particles that are in the gas phase in the liquid, such as mercury atoms, oxygen atoms or hydrogen atoms, are to be measured, the particles should hit the sensor surface at a certain speed to give the particles the energy needed to detach them from the liquid and react with the coating on the sensor. surface. Thus, in such applications, a high flow rate is required in the measuring chamber in the direction of the surface of the sensor to give the particles a sufficiently high speed for them to reach the surface of the sensor and react with the coating on the surface of the sensor.
One way to increase the velocity in the measuring chamber is to increase the flow velocity in the inlet duct by increasing the speed of the pump. If the velocity in the inlet duct is increased, the pressure in the measuring chamber will also increase, which can lead to damage to While it is desirable in applications with high flow velocities near the surface of the sensor, it is thus important that the flow velocity is increased. the sensor and that the sensitivity of the sensor decreases. some pressure in the measuring chamber does not rise when Depending on what the sensor is to detect, an adjustment of the flow past the sensor surface is thus required. Today, different types of measuring cells adapted for different types of measurements are manufactured.
There are also other applications where it is desirable to have high ﬂ velocities in a space, such as fuel cells. OBJECTS AND SUMMARY OF THE INVENTION An object of the present invention is to provide a device which makes it possible to control the liquid flow in a space so that the flow can be changed depending on the application.
Another object of the present invention is to provide a device which makes it possible to greatly increase the rate of destruction of the liquid in the space without there being an undesired increase in pressure in the space.
A further object of the present invention is to provide a device which makes it possible to achieve a higher speed of destruction in the space than the pump is capable of providing. These objects are achieved with a device as defined in claim 1.
The device is characterized in that the space is provided with a third opening, and that the duct system comprises a distribution chamber connected to the inlet duct and a third channel connected between the distribution chamber and the third opening for transporting liquid between the distribution chamber and the space.
The pump is arranged so that it can vary the fate rate of the liquid in the distribution chamber between a lower and a higher rate of fate, and the third channel is arranged so that its direction of transport depends on the rate of fate in the distribution chamber so that the liquid in the third channel is transported in the direction of the distribution chamber. at the lower ﬂ velocity velocity in the distribution chamber, which leads to a calm and quiet flow in the space, and in the opposite direction, ie. in the direction from the space to the distribution chamber, at the higher flow rate in the distribution chamber due to the injector action, which leads to a sharply increased flow rate in the inlet duct and thus in the space.
Thanks to the fact that the device has two channels between the distribution chamber and the space and the pump is arranged so that it can control the flow rate in the distribution chamber, it is possible to generate different types of flows in the space.
The invention makes it possible to alternate between a slow and a very fast flow in the space by making only a small change in the speed of the pump.
At moderate flow rates in the distribution chamber, the liquid in the third channel will flow in the same direction as the liquid in the inlet channel. Thus, the flow to the space will be distributed between the two channels and leading to steady flow in When the flow rate increases in the distribution chamber and the static pressure in the distribution chamber decreases relative to the static pressure in the space, and when the ﬂ velocity velocity in the distribution chamber boundary velocity has decreased in the distribution chamber so much relative to the pressure in the space that the flow in it a calm and the space. exceeds a certain third channel changes direction, so-called injector effect. Thus, the flow from the third channel is added to the flow that passes the inlet channel, which leads to the flow velocity in the inlet channel, and thus in the space, increasing further. In this way, a greater flow is achieved than what the pump generates. This makes it possible to use a simple and cheap pump and still achieve a high fate. Due to the fact that the liquid flows from the space through the third inlet duct, the pressure in the space decreases despite the fact that the speed of fate in the inlet duct increases, and thus pressure build-up in the space is avoided.
According to an embodiment of the invention, the distribution chamber is arranged so that it has a defined direction of fate, and the inlet channel and the third channel are arranged perpendicular to the direction of fate in the distribution chamber. To achieve an injector effect, the direction of fate in the inlet channel and the third channel should be substantially perpendicular to the flow direction in the distribution chamber.
However, a certain deviation is allowed.
According to an embodiment of the invention, the third channel is parallel to the inlet channel, and the third inlet channel is in the range 1 - 2.5 mm. the center distance between that channel and According to an embodiment of the invention, the difference between the cross-sectional area of the inlet channel and the cross-sectional area of the third channel is less than 20%.
Preferably, the cross-sectional areas of the inlet channel and the third channel are equal in size. Because the inlet channel and the third channel have approximately the same cross-sectional area, the fate volumes in both channels become approximately equal.
Since the flow in the third channel is opposite to the flow in the inlet channel, an increase in the pressure in the space is thus avoided when the ﬂ velocity velocity increases in the inlet channel.
According to an embodiment of the invention, the outlet channel has a cross-sectional area which is at least 50%, preferably 100% larger than the cross-sectional area of the inlet channel.
The outlet duct must have a cross-sectional area which is substantially larger than the inlet duct for the transport of the liquid away and thereby avoid pressure build-up in the space. According to the flow rate in the distribution chamber can thereby be controlled in a simple manner an embodiment of the invention, the pump has speed control. by varying the speed of the pump.
According to an embodiment of the invention, the device comprises a sensor arranged opposite the inlet opening and the third opening in the space for measuring substances in the liquid in the space. The third opening and the inlet duct are arranged so that they face the sensor. This embodiment makes it possible to alternate between different types of flows at the surface of the sensor by varying the speed of fate in the distribution chamber. A lower ﬂ velocity velocity in the distribution chamber provides a calm and steady flow past the surface of the sensor.
This gives the particles to be measured a longer residence time in the chamber and at the sensor. This type of flow is beneficial in measuring particles that bind to peptide, which is a time consuming process. A higher ﬂ velocity velocity in the distribution chamber leads, due to the injector effect, to a greatly increased ﬂ velocity velocity in the inlet duct and thus a strong ﬂ fate to the sensor and a short residence time for the particles in the space. The strong flow towards the sensor causes an increased energy when the particles hit the sensor surface, and which increases the tendency to loosen particles that are in gaseous form in the liquid, and thus increases the possibility of detecting the particles. This leads to faster measurement and increased sensitivity in the measurement.
The invention is very suitable for measuring substances which require biochemical reactions on the surface of the sensor.
The invention makes it possible to use the same measuring cell to measure different types of preparations which require different chemical reactions on the surface of the sensor. Preferably, the device is designed so that the sensor is replaceable. It is sufficient to replace the sensor in a new type of preparation. This leads to a reduction in production costs and costs for storage of measuring cells. cell when measured.
When the flow in the distribution chamber, due to the injector action, a loop is made which makes the third channel take place in the direction from the space so that some of the liquid, with the particles to be measured, will pass the sensor several times and thus increase the chance of the particles being measured .
According to an embodiment of the invention, the distance between the inlet opening and the sensor should be between 0.8 and 1 mm. This embodiment ensures that the flow reaches all the way to the sensor, while a pressure build-up in the space is avoided. To avoid a build-up of pressure in the space, the flow resistance in the space should be as low as possible. To avoid pressure build-up in the space, it is therefore desirable that the distance between the inlet opening and the sensor is as large as possible. But the greater the distance between the inlet opening and the sensor, the higher the speed of fate in the inlet duct is needed to make the fate reach the sensor. It has been found that if the distance between the inlet opening and the sensor is between 0.8 and 1 mm, it is possible for the flow to reach the surface of the sensor, with only a low pressure build-up in the sensor. According to an embodiment of the invention, the inlet opening, the outlet opening and the third opening are arranged in line with each other. This provides a favorable flow past the sensor.
According to an embodiment of the invention, the inlet opening is arranged between the outlet opening and the third opening. In this way, undesired turbulence in the space is avoided when the device operates under the injector action.
According to an embodiment of the invention, the inlet duct is arranged with its longitudinal axis perpendicular to the distribution surface of the sensor. Thus, the flow is directed straight towards the sensor and the flow reaches as close to the surface of the sensor as possible.
Brief Description of the Drawings The invention will now be explained in more detail by describing various embodiments of the invention and with reference to the accompanying drawings.
Figure 1 shows an example of a device for controlling a liquid fate in a space according to the invention.
Figure 2 shows a section A-A through the device in figure 1.
Figure 3 shows the fate to and from the sensor in the device of Figure 1 when operating in a first state.
Figure 4 shows the flow to and from the sensor in the device of Figure 1 when operating in a second state.
Figure 5 shows the fate to and from the sensor in the device of Figure 1 when operating in a third state.
Detailed Description of Preferred Embodiments of the Invention Figure 1 shows an example of a device according to the invention for controlling a liquid i fate in a space. Figure 2 shows a section A-A through the device in figure 1.
In this embodiment, the device forms part of a measuring cell for detecting and measuring substances in a sample. A sample is added to a liquid that is circulated in the measuring cell.
The device comprises a body 1 which contains a space 4 in the form of an elongate measuring chamber with an inlet opening 5 for receiving the liquid containing the sample to be measured, an outlet opening 6 for removing the liquid after measurement, and a duct system for transporting liquid to and from the measuring chamber. The duct system forms a closed loop. The body 1 is preferably made of a plastic material such as Polyetheretherketone (PEEK) or acrylic plastic, but can also be made of glass. The device comprises a sensor 10 arranged in the measuring chamber. The sensor 10 is located along the longitudinal axis of the chamber and opposite the inlet opening 5. Preferably, the measuring cell is designed so that the sensor can be replaced by another sensor in order to be able to perform other types of measurements.
The device comprises two seals 7, for example, in the form of O-rings, for sealing around the sensor.
The duct system comprises an inlet duct 8 connected to the inlet opening 5 of the measuring chamber for transporting liquid to the measuring chamber, and an outlet duct 9 connected to the outlet opening 6 of the measuring chamber for transporting liquid from the measuring chamber. The measuring chamber 4 is provided with a third opening 12 arranged so that it faces the sensor 10. All three openings 5,6,12 are arranged on a line.
The inlet opening 5 is arranged between the outlet opening 6 and the third opening 12. The duct system comprises a third channel 14, hereinafter referred to as injector channel, connected to the third opening 12 of the measuring chamber 12. The inlet channel 8, the outlet channel and the third channel 14 are arranged parallel to each other.
Preferably, the inlet duct and the injector duct are arranged with their longitudinal axes perpendicular to the distribution surface of the sensor, and thus perpendicular to the longitudinal axis of the measuring chamber. The injector duct is arranged upstream of the inlet opening. In this embodiment of the invention, the inlet duct is arranged between the outlet duct and the injector duct.
If the injector duct were instead arranged between the outlet duct and the inlet duct, and the flow direction in the distribution chamber is the opposite, it would lead to a lot of turbulence in the measuring chamber when the device works in with injector action. In another embodiment, where there is no sensor in the space, it would be possible to have the outlet duct on some other wall in the space, for example arranged on the opposite side to the inlet duct and the injector duct.
The duct system further comprises a distribution chamber 15 arranged in connection with the inlet duct 8 and the injector duct 14. The purpose of the distribution chamber 15 is to distribute the mellan between the inlet duct 8 and the injector duct 14.
The injector channel 14 is connected between the distribution chamber 15 and the third opening 12 for transporting liquid between the distribution chamber and the measuring chamber. The inlet duct 8 is connected between the distribution chamber 15 and the inlet opening 5 for transporting liquid from the distribution chamber to the measuring chamber. One end of the distribution chamber has an opening 16 for receiving liquid and its opposite end is connected to the inlet channel 8.
The distribution chamber 15 is arranged so as to have a defined flow direction 18 and the inlet channel 8 and the third channel 14 are arranged perpendicular to the direction of fate in the distribution chamber, as shown in Figure 3.
The distribution chamber 15 is elongate and extends the measuring chamber. The inlet channel 8 and the injector channel 14 are arranged with their lengths parallel to longitudinal axes perpendicular to the longitudinal axis of the distribution chamber.
The distance a between the inlet opening and the sensor should be less than or equal to 1 mm, preferably between 0.8 and 1 mm. a <= lmm In a preferred embodiment, the inlet duct, the outlet duct and the injector duct have a circular cross-sectional area, as shown in Figure 2. In the embodiment shown in Figures 1 and 2, the inlet duct 8 and the injector duct 14 have the diameter di = dz = lmm, and 9 have the outlet duct diameter dg = 1.6 mm. It is also possible to use channels with other shapes, such as a rectangular cross section. Preferably, the cross-sectional area of the inlet duct and the cross-sectional area of the injector duct should be equal. The difference between the cross-sectional area of the inlet duct and the cross-sectional area of the injector duct should To avoid pressure build-up in the measuring chamber, the outlet duct larger than the cross-sectional area of should not exceed 20%. cross-sectional area of the inlet duct and the injector duct. Preferably, the outlet channel has one which is at least 50%, and preferably at least 100% larger than the cross-sectional area of the inlet channel. The center distance 1 between the third opening 12 and the inlet opening 5 is in the range 1 - 2.5 mm and is typically 2 mm.
The Vafa device comprises a pump 17 arranged to pump around the liquid in the duct system. The pump is, for example, a friction pump, such as that shown in WO2005 / 121744. The pump 17 is arranged so that it can vary the flow rate of the liquid in the distribution chamber 15 between a lower and a higher flow rate. Preferably, the pump is arranged so that it can continuously change the flow rate in the distribution chamber from zero up to a maximum value. In order to achieve a variable fate rate in the distribution chamber, the pump is advantageously provided with speed control. By regulating the speed of the pump, the flow rate in the distribution chamber can be controlled.
The injector channel 14 is arranged so that its transport direction depends on the flow rate in the distribution chamber in such a way that the liquid is transported in the direction from the distribution chamber 15 to the measuring chamber 4 at a low flow velocity in the distribution chamber, leading to a quiet flow past the sensor, and in the opposite direction at a higher flow direction. in the distribution chamber due to the injector action, which leads to a greatly increased flow rate in the inlet duct and thus a strong ﬂ fate towards the sensor.
The following describes how a device according to the invention can control the flow past the surface of the sensor. The device can operate in three different states, which give rise to different types of flows in the measuring chamber. Figure 3 shows the fate to and from the sensor in the device of Figure 1 when operating in a first state. This condition is achieved by running the pump at low or moderate speeds, which means that the flow rate in the distribution chamber 15 varies from low up to moderate. In the first state, the liquid flows in the injector channel 14 in the same direction as in the inlet channel 8, i.e. in the direction from the distribution chamber 15 to the measuring chamber 4. This leads to a calm and quiet fate past the sensor and thus gives the sample a long residence time in the measuring chamber. This is advantageous, for example, when measuring substances that require a long time to react with the coating on the surface of the sensor.
This type of flow is beneficial, for example, in measuring particles, such as arsenic, that bind to peptide, which is a time consuming process.
Figure 4 shows the flow to and from the sensor when the device is operating in a second state. When the pump distribution chamber to increase. As the flow rate increases in the distribution chamber and the static pressure in the distribution chamber will decrease relative to the speed increased, the d velocity velocity in the static pressure in the measuring chamber will increase. When the rate of fate in the distribution chamber reaches a critical speed, the pressure in the distribution chamber will be the same as in the measuring chamber, which leads to the flow in the injector channel stopping and all transport of liquid from the distribution chamber to the measuring chamber taking place via the inlet channel. The device is now operating in its second state. and thus the speed of fate in it will be further increased, If the speed of the pump distribution chamber is further increased, the static pressure in the distribution chamber will decrease relative to the static pressure in the measuring chamber, so that the pressure in the distribution chamber will be less than the pressure in the measuring chamber. that ﬂ the fate of the injector channel changes direction due to the injector action.
The device now proceeds to operate in its third state, as shown in Figure 5. In this state, the liquid in the injector channel flows from the measuring chamber to the distribution chamber at the same time as the liquid in the inlet channel flows from the distribution chamber to the measuring chamber.
The fact that liquid flows from the measuring chamber to the distribution chamber leads to an increased volume of liquid in the distribution chamber. Since water cannot be compressed, this causes a sharp increase in the ﬂ velocity velocity in the inlet channel.
This means that the flow from the injector channel is added to the flow in the inlet channel.
In this way, a greater ﬂ fate is achieved in the inlet duct than what the pump itself is able to generate. The high ﬂ velocity velocity in the inlet duct causes the liquid ﬂ fate to reach all the way to the surface of the sensor, as shown in Figure 5. The strong mot fate towards the sensor causes particles in the liquid to be thrown towards the sensor surface with a certain force, giving the particles the energy needed to release them from the liquid and react with the coating on the surface of the sensor, thereby increasing the ability to detect the particles. A higher flow velocity in the distribution chamber thus leads to a sharply increased ﬂ velocity velocity in the inlet duct and thus a strong flow towards the sensor and a short residence time for the particles in the measuring chamber. This is advantageous, for example, in the measurement of light particles which are in the gas phase in the liquid, for example mercury atoms, oxygen atoms or hydrogen atoms.
As shown in Figure 5, the third channel 14 and the inlet channel 8 form a loop which causes some of the liquid to pass the sensor ﬂ times and thus increases the chance that the sensor detects the particles.
By replacing the sensor in the measuring cell and changing the speed of the pump, the same measuring cell can thus be used for different types of measurements.
The present invention is not limited to the embodiment shown but can be varied and modified within the scope of the appended claims. For example, contain any Furthermore, the length of the space required for the measuring chamber and the distribution chamber may not vary. The size of the device can SGIISOT. of course vary depending on how large volumes of liquid are to pass through the space.
Thanks to the simple construction, it is easy to resize the device and design it for flows of different volume sizes. It is possible to scale down the device so that it can control flows in the order of ul / s.

权利要求:
Claims (3)
[1]
Device for controlling a liquid ﬂ fate in a space (4) with an inlet opening (5) and an outlet opening (6), the device comprising a channel system for transporting liquid to and from the space comprising o an inlet channel (8) connected to the inlet opening of the space for transporting liquid to the space, and an outlet channel (9) connected to the outlet opening of the space for transporting liquid from the space, and a pump (17) arranged to pump the liquid into the duct system, characterized in that the space is provided with a third opening (12), the duct system comprising o a distribution chamber (15) connected to the inlet duct, and o a third duct (14) connected between the distribution chamber and said third opening for transporting liquid between the distribution chamber and the space, the pump being arranged so as to vary the liquid ﬂ fate rate in the distribution chamber between a lower and a higher ﬂ fate rate, and the third channel is arranged so that its direction of transport depends on the ﬂ velocity velocity in the distribution chamber in this way the liquid into the third channel is transported in the direction from the distribution chamber to the space at the lower ﬂ velocity velocity in the distribution chamber, leading to a steady flow in the space, and in the opposite direction , which leads to a greatly increased flow rate in the inlet duct and thus in the space.
[2]
Device according to claim 1, characterized in that the distribution chamber (15) is arranged so that it has a defined direction of fate (18), and the inlet channel (8) and the third channel (14) are arranged perpendicular to the flow direction in the distribution chamber.
[3]
Device according to claim 1 or 2, characterized in that the third channel (14) is parallel to the inlet channel (8) and the center distance between the third channel and the inlet channel is in the range 1 - 2.5 mm. 10 15 20 25 30 12. Device according to one of the preceding claims, characterized in that the difference between the cross-sectional area of the inlet duct (8) and the cross-sectional area of the third duct (14) is less than 20%. . Device according to one of the preceding claims, characterized in that the outlet channel (9) has a cross-sectional area which is at least 50%, preferably 100% larger than the cross-sectional area in the inlet channel (8). . Device according to one of the preceding claims, characterized in that the inlet opening (5), the outlet opening (6) and the third opening (12) are arranged in line with each other, and the inlet opening is arranged between the outlet opening and the third opening. . Device according to one of the preceding claims, characterized in that the device comprises a sensor (10) arranged opposite the inlet opening and the third opening in the space for measuring substances in the liquid in the space. . Device according to claim 7, characterized in that the inlet channel (8) and the third channel (14) are arranged with their long axes perpendicular to the distribution surface of the sensor (10). . Device according to Claim 7 or 8, characterized in that the distance (a) between the inlet opening (5) and the surface of the sensor is between 0.8 and 1 mm. Device according to one of Claims 7 to 9, characterized in that the device is designed so that the sensor is replaceable.

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同族专利:

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SE535988C2|2013-03-19|

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引用文献:

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

WO2005121743A1|2004-06-09|2005-12-22|G2 Ingenjörsbyrå Ab|Flow cell with continuously circulating fluid|

US20060257290A1|2005-04-13|2006-11-16|Fuji Photo Film Co., Ltd.|Fluid dispenser, fluid dispensing method and assay apparatus for assay in utilizing attenuated total reflection|

FR2931085B1|2008-05-13|2011-05-27|Commissariat Energie Atomique|METHOD OF SORTING PARTICLES OR AMAS FROM PARTICLES IN A FLUID CIRCULATING IN A CHANNEL|

JP2011221009A|2010-03-25|2011-11-04|Fujifilm Corp|Biological material detection device|JP6549747B2|2017-04-14|2019-07-24|リオン株式会社|Particle measuring apparatus and particle measuring method|

法律状态:

优先权:

申请号 | 申请日 | 专利标题

SE1230030A|SE535988C2|2012-03-22|2012-03-22|Device for controlling a fluid flow in a space|SE1230030A| SE535988C2|2012-03-22|2012-03-22|Device for controlling a fluid flow in a space|

PCT/EP2013/055643| WO2013139768A1|2012-03-22|2013-03-19|A device for controlling a fluid flow in a compartment|

US14/387,035| US9110045B2|2012-03-22|2013-03-19|Device for controlling a fluid flow in a compartment|

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